Dysfunctional Gut Microbiome Networks in Childhood IgE-Mediated Food Allergy

The development of food allergy has been reported to be related with the changes in gut microbiome, however specific microbe associated pathogenesis remains elusive. This study aimed comprehensively characterize microbiome and identify individual or group microbes relating food-allergy using 16S rRNA gene sequencing network analysis. Faecal samples were collected from children IgE-mediated allergies (n = 33) without 27). Gut was profiled by sequencing. OTUs obtained then used construct a co-abundance Weighted Gene Co-expression Network Analysis (WGCNA) mapped onto Kyoto Encyclopedia Genes Genomes (KEGG) pathways. We identified module positively correlated this characterized hub taxon, namely Ruminococcaceae UCG-002 (phylum Firmicutes). Functional pathway analysis all showed enrichment methane metabolism glycerolipid food-allergic ubiquinone other terpenoid-quinone biosynthesis non-food allergic children. concluded that may play determinant roles microbial community structure function leading allergy.